Toward global RNA structure analysis
نویسندگان
چکیده
منابع مشابه
Global analysis of RNA secondary structure in two metazoans.
The secondary structure of RNA is necessary for its maturation, regulation, processing, and function. However, the global influence of RNA folding in eukaryotes is still unclear. Here, we use a high-throughput, sequencing-based, structure-mapping approach to identify the paired (double-stranded RNA [dsRNA]) and unpaired (single-stranded RNA [ssRNA]) components of the Drosophila melanogaster and...
متن کاملGlobal analysis of the RNA-protein interaction and RNA secondary structure landscapes of the Arabidopsis nucleus.
Posttranscriptional regulation in eukaryotes requires cis- and trans-acting features and factors including RNA secondary structure and RNA-binding proteins (RBPs). However, a comprehensive view of the structural and RBP interaction landscape of nuclear RNAs has yet to be compiled for any organism. Here, we use our ribonuclease-mediated structure and RBP-binding site mapping approaches to global...
متن کاملRNA structure: experimental analysis.
Among all of the biological macromolecules, the functional versatility of RNAs is unique including encoding or transferring genetic information and performing catalysis. These biological functions are highly dependent upon RNA folding and structure. Since the discovery of catalytic RNAs in the early 1980s, a recent breakthrough came from the identification of a wealth of micro RNAs, small inter...
متن کاملRNA StrAT : RNA Structure Analysis Toolkit
Summary: We present a web server dedicated to the comparison of RNA secondary structures. This server allows to compare pairs of RNA secondary structures and to search, for a given RNA secondary structure, RNA genes with similar structures in a large database of RNA structures. The comparison and search are performed using an edit distance algorithm that considers a wide range of edit operation...
متن کاملToward a next-generation atlas of RNA secondary structure
RNA structure plays a crucial role in gene maturation, regulation and function. Determining the form and frequency of RNA folds is essential for a better understanding of how RNA exerts its functions. Low-throughput studies have focused on RNA primary sequences and expression levels, but with an emphasis on relatively small numbers of transcripts. However, with the recent advent of high-through...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2010
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt1110-1178